Louisiana : storia di un uomo e di un museo / Knud W. Jensen ; con un saggio di Michael Brawne |
Autore | Jensen, Knud W. |
Edizione | [Ed. italiana] |
Pubbl/distr/stampa | Bologna, : C.L.U.E.B., c1996 |
Descrizione fisica | 280 p., [30] c. di tav. : ill. ; 22 cm |
Disciplina | 708.89 |
Collana | Lexis, Museo Poli |
Soggetto non controllato | Humlebaek - Museo Louisiana - Storia |
ISBN | 88-8091-311-5 |
Formato | Materiale a stampa |
Livello bibliografico | Monografia |
Lingua di pubblicazione | ita |
Record Nr. | UNINA-990007009240403321 |
Jensen, Knud W. | ||
Bologna, : C.L.U.E.B., c1996 | ||
Materiale a stampa | ||
Lo trovi qui: Univ. Federico II | ||
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Om Louisianas graeske samling / af Knud W. Jensen |
Autore | Jensen, Knud W. |
Pubbl/distr/stampa | [s.l.], : [s.n.], [1958] |
Descrizione fisica | P. 11-20 : ill. ; 35 cm |
Formato | Materiale a stampa |
Livello bibliografico | Monografia |
Lingua di pubblicazione | ? |
Record Nr. | UNINA-990005404390403321 |
Jensen, Knud W. | ||
[s.l.], : [s.n.], [1958] | ||
Materiale a stampa | ||
Lo trovi qui: Univ. Federico II | ||
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Peptide and protein design for biopharmaceutical applications [[electronic resource] /] / editor, Knud J. Jensen |
Pubbl/distr/stampa | West Sussex, UK ; ; Hoboken, NJ, : Wiley, 2009 |
Descrizione fisica | 1 online resource (314 p.) |
Disciplina | 615.19 |
Altri autori (Persone) | JensenKnud J |
Soggetto topico |
Peptide drugs - Design
Protein drugs - Design Peptides - Design Protein engineering |
ISBN |
1-282-29176-9
9786612291760 0-470-74971-7 0-470-74970-9 |
Formato | Materiale a stampa |
Livello bibliografico | Monografia |
Lingua di pubblicazione | eng |
Nota di contenuto |
Peptide and Protein Design for Biopharmaceutical Applications; Contents; List of Contributors; Preface; 1 Introduction; 2 Computational Approaches in Peptide and Protein Design: An Overview; 2.1 Introduction; 2.2 Basics and Tools; 2.2.1 The Importance of Computational Approaches; 2.2.2 Tools and Procedures: Force Fields and Sampling; 2.3 Computational Study of Cyclopentapeptide Inhibitors of CXCR4; 2.3.1 The 3D Pharmacophore Model for FC131; 2.3.2 A 3D Model of the TM Region of CXCR4; 2.3.3 Docking of FC131 to CXCR4; Acknowledgements; References; 3 Aspects of Peptidomimetics; 3.1 Introduction
3.2 Modified Peptides3.3 Pseudopeptides; 3.4 Secondary Structure Mimics (Excluding Turn Mimics); 3.4.1 -strand Mimetics; 3.4.2 Helix Mimetics; 3.5 Examples of Peptidomimetics; 3.6 Conclusion; References; 4 Design of Cyclic Peptides; 4.1 Introduction; 4.1.1 Pharmaceutical Research Today; 4.1.2 General Advantages of Cyclic Peptide Structures; 4.1.3 Examples of Cyclic Peptides of Medicinal Interest; 4.1.4 General Considerations; 4.2 Peptide Cyclization; 4.2.1 Possibilities of Peptide Cyclization; 4.2.2 Synthesis of Cyclic Peptides; 4.2.3 Chemical Modifications of Cyclic Peptides 4.2.4 Concluding Remarks4.3 Conformation and Dynamics of Cyclic Peptides; 4.3.1 Reductions in Conformational Space; 4.3.2 Conformational Arrangements in Cyclic Structures; 4.3.3 Flexibility of Cyclized Scaffolds; 4.3.4 Experimental Structure Characterization; 4.4 Concepts in the Rational Design of Cyclic Peptides; 4.4.1 The Influence of Amino Acid Composition; 4.4.2 The Dunitz-Waser Concept; 4.4.3 The Spatial Screening Technique; 4.4.4 General Strategy for Finding Active Hits; 4.5 Examples of Cyclic Peptides as Drug Candidates; 4.5.1 Cilengitide as Integrin Inhibitor; 4.5.2 CXCR4 Antagonists 4.5.3 Sandostatin and the Veber-Hirschmann Peptide as Examples of Rational Design4.6 Conclusion; References; 5 Carbohydrates in Peptide and Protein Design; 5.1 Introduction; 5.2 Configurational and Conformational Properties of Carbohydrates; 5.3 Carbohydrates in Peptidomimetics; 5.4 Glycopeptides; 5.5 Carbohydrates as Scaffolds in the Design of Nonpeptide Peptidomimetics; 5.6 Sugar Amino Acids; 5.7 Cyclodextrin-Peptide Conjugates; 5.8 Carboproteins: Protein Models on Carbohydrate Templates; 5.9 Conclusion; References; 6 De Novo Design of Proteins; 6.1 Introduction 6.2 Secondary Structure Elements6.2.1 The -helix; 6.2.2 The -sheet; 6.2.3 Loops, Turns and Templates; 6.3 Assembling a Specified Tertiary Structure from Secondary Structural Elements; 6.3.1 Computational Methods; 6.3.2 Coiled Coils; 6.3.3 -helical Bundles; 6.3.4 Fluorous Interactions; 6.3.5 Additional Topics; 6.4 Proteins on Templates; 6.5 Foldamers; 6.6 Biopharmaceutical Applications of De Novo Design; 6.6.1 -helical Structures in Biopharmaceutical Applications; 6.6.2 Foldamers in Biopharmaceutical Applications; References 7 Design of Insulin Variants for Improved Treatment of Diabetes |
Record Nr. | UNINA-9910139761503321 |
West Sussex, UK ; ; Hoboken, NJ, : Wiley, 2009 | ||
Materiale a stampa | ||
Lo trovi qui: Univ. Federico II | ||
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